Clinical effects of a cation-exchange resin (Zeo-Karb 225).

Properties and limitations of a cation-exchange resin. Laboratory investigation of Zeo-Karb 225.

Separation and characterization of urinary indoles resembling 5-hydroxytryptamine and tryptamine.

The occurrence of 5-hydroxytryptamine (serotonin) in normal human urine is suggested by the experiments of Page and his co-workers. Twarog & Page (1953) examined acetone extracts of urine by a pharmacological method (isolated heart of Venus mercenaria) and reported a 'serotonin-like activity' equivalent to 0'1-10yeg. of 5-hydroxytryptamine/ ml. ofurine. Later, Bumpus&Page (1955) described indol...

Displacement Chromatography on Synthetic Ion - exchange Resins

In Part 1 of this series of papers (Partridge & Westall, 1949) it was shown that, whilst the baseexchange resin Zeo Karb 215 may be used with success for the separation of the neutral and acidic amino-acids, certain difficulties arise when the separation of basic substances is attempted. These difficulties were traced to the phenolic hydroxyl groups of the resin. Resins of the sulphonated pheno...

Displacement chromatography on synthetic ion-exchange resins. 2. The separation of organic acids and acidic amino-acids by the use of anion-exchange resins.

The application of the principle of displacement chromatography to the separation of bases and amino-acids on columns packed with the cationexchange resin Zeo-Karb 215 has been described in Part 1 of this communication (Partridge & Westall, 1949). It is expected that this method will prove to be of value in the isolation of bases and amino-acids from biological extracts of various kinds, and th...

Effects of Weak and Strong Cation Exchange Resins on Moisture Uptake Behavior of Ranitidine Hydrochloride

     The aim of the present research was to study the effects of weak cation exchange resins, polacrilex with exchangeable H+ and polacrillin potassium and strong cation exchange resin sodium polystyrene sulfonate on water uptake behavior of ranitidine hydrochloride. Drug resin complexes (DRC) were prepared and evaluated for the percentage of moisture gain when placed in a humidity c...